Argonautes and Company: sailing against the wind

Bhattacharyya, Suvendra N. ; Filipowicz, Witold (2007) Argonautes and Company: sailing against the wind Cell, 128 (6). pp. 1027-1028. ISSN 0092-8674

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The 3′-untranslated region (UTR) of mRNA is crucial for posttranscriptional regulation. In this issue, Vasudevan and Steitz (2007)) report a new function for AGO2 and FXR1—two proteins that have been linked to the regulation of microRNAs and translation repression. AGO2 and FXR1 bind to the AU-rich element in the 3′-UTR of TNFα mRNA, unexpectedly activating its translation in a cell growth-dependent manner.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:108153
Deposited On:01 Feb 2018 11:12
Last Modified:01 Feb 2018 11:12

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