Aminoethylprolyl peptide nucleic acids (aepPNA): chiral PNA analogues that form highly stable DNA:aepPNA2 triplexes

D'Costa, Moneesha ; Kumar, Vaijayanti A. ; Ganesh, Krishna N. (1999) Aminoethylprolyl peptide nucleic acids (aepPNA): chiral PNA analogues that form highly stable DNA:aepPNA2 triplexes Organic Letters, 1 (10). pp. 1513-1516. ISSN 1523-7060

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Official URL: http://pubs.acs.org/doi/abs/10.1021/ol990835i

Related URL: http://dx.doi.org/10.1021/ol990835i

Abstract

The replacement of the glycyl component in the peptide nucleic acid (PNA) backbone by a prolyl unit bearing a nucleobase leads to the aminoethylprolyl (aep) PNAs, which are chiral and cationic. The homooligomeric aepPNA binds to complementary DNA sequences with high affinity and sequence specificity, forming highly stable triplexes.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:10805
Deposited On:09 Nov 2010 04:50
Last Modified:31 May 2011 09:47

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