D'Costa, Moneesha ; Kumar, Vaijayanti ; Ganesh, Krishna N. (2001) Aminoethylprolyl (aep) PNA: mixed purine/pyrimidine oligomers and binding orientation preferences for PNA:DNA duplex formation Organic Letters, 3 (9). pp. 1281-1284. ISSN 1523-7060
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Official URL: http://pubs.acs.org/doi/abs/10.1021/ol015546k
Related URL: http://dx.doi.org/10.1021/ol015546k
Abstract
The synthesis of (2S,4S)- and (2R,4S)-aepPNA monomers of adenine, guanine, and cytosine (3-5) and their incorporation at appropriate positions into aegPNA sequence 7 leads to mixed aeg-aep backbone/mixed nucleobase PNAs 8-11. The thermal stabilities of the derived duplexes with DNA are found to be dependent on nucleobase and backbone stereochemistry.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 10797 |
| Deposited On: | 09 Nov 2010 04:52 |
| Last Modified: | 31 May 2011 09:31 |
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