Stabilization of collagen using plant polyphenol: role of catechin

Madhan, B. ; Subramanian, V. ; Rao, J. Raghava ; Nair, Balachandran Unni ; Ramasami, T. (2005) Stabilization of collagen using plant polyphenol: role of catechin International Journal of Biological Macromolecules, 37 (1-2). pp. 47-53. ISSN 0141-8130

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Collagen, a unique connective tissue protein finds extensive application as biocompatible biomaterial in wound healing, as drug carriers, cosmetics, etc. A work has been undertaken to study the stabilization of type I collagen using the plant polyphenol catechin. Catechin treated collagen fibres showed a shrinkage temperature around 70°C implying that catechin is able to impart thermal stability to collagen. Catechin treated collagen fibres has been found to be stable even after treatment with high concentration of the secondary structural destabilizer, urea. Circular dichroism studies revealed that there is no major alteration in the structure of collagen on treatment with catechin. The study has demonstrated the involvement of hydrogen bonding and hydrophobic interactions as the major forces involved in the stabilization of collagen by the plant polyphenol, catechin.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Collagen; Catechin; Polyphenol; Rat Tail Tendon (RTT); Tannin
ID Code:107857
Deposited On:01 Dec 2017 12:18
Last Modified:01 Dec 2017 12:18

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