Joshi, Rajendra R. ; Ganesh, K. N. (1994) Duplex and triplex directed DNA cleavage by oligonucleotide-Cu(II)/Co(III) metallodesferal conjugates Biochimica et Biophysica Acta: General Subjects, 1201 (3). pp. 454-460. ISSN 0304-4165
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/030441...
Related URL: http://dx.doi.org/10.1016/0304-4165(94)90076-0
Abstract
Cu(II) desferal conjugated to d(T)10 at 5'-end is shown to direct the cleavage of single stranded 19-mer target DNA d(TA1GCCCG-GCG), with a base preference G > C » A. In contrast, the corresponding Co(II)-desferal conjugate directed the cleavage specific to only G sites (G12, G16, G17 and G19). Triplex targetting on the duplex 5t'-TCCTGATAAAGGAGGAGATGAAGAAAAAATGA-3': 3'AGGACTATTTCCTCCTCTACTTCTTTTTTACT-5', using Cu(II) desferal conjugated to 5'-end of 3'-TTTCCTCCTCT-5' directed the cleavage at G5.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | DNA Cleavage; Targeted Cleavage |
| ID Code: | 10784 |
| Deposited On: | 09 Nov 2010 04:55 |
| Last Modified: | 31 May 2011 09:56 |
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