Exploring DNA minor groove interactions through a probe conjugate in major groove: fluorescence studies on netrosin complexation with dU-5-aminodansyl-DNA

Barawkar, D. A. ; Ganesh, K. N. (1994) Exploring DNA minor groove interactions through a probe conjugate in major groove: fluorescence studies on netrosin complexation with dU-5-aminodansyl-DNA Biochemical and Biophysical Research Communications, 203 (1). pp. 53-58. ISSN 0006-291X

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00062...

Related URL: http://dx.doi.org/10.1006/bbrc.1994.2147

Abstract

The binding of netropsin to 5-Aminodansyl-dU-DNA (2-5) in minor groove is shown to correlate with fluorescence changes of dansyl fluorophore located in major groove. This enables a study of a minor groove binding event through crosstalk with conjugated probe in major groove. The dielectric constant of major groove estimated from fluorescence properties of (2-6) is about 55D in contrast to the literature reported minor groove dielectric constant of 20D in the poly[d(AT)]-poly[d(AT)] duplex.

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