Analysis of genetic variants in the IL4 promoter and VNTR loci in Indian patients with Visceral Leishmaniasis

Mishra, Anshuman ; Jha, Aditya Nath ; Tong, Hoang van ; Singh, Vipin Kumar ; Gomes, Carlos E. M. ; Singh, Lalji ; Velavan, Thirumalaisamy P. ; Thangaraj, Kumarasamy (2014) Analysis of genetic variants in the IL4 promoter and VNTR loci in Indian patients with Visceral Leishmaniasis Human Immunology, 75 (12). pp. 1177-1181. ISSN 0198-8859

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.humimm.2014.10.007

Abstract

Visceral Leishmaniasis (VL) is the most severest form of Leishmaniasis and resistance to infection is mediated by cellular immune responses. Interleukin 4 (IL-4) orchestrates of Th2 and Th1 immune responses during infections. In this study, we aimed to investigate possible association between three functional IL-4 polymorphisms −590C/T (rs2243250), −34C/T (rs2070874) and 70bp VNTR (rs79071878 in intron3) with VL in an Indian cohort comprising of 197 VL patients and 193 healthy controls. The three investigated IL-4 polymorphisms were in strong linkage disequilibrium. The investigated IL-4 alleles, genotypes and the reconstructed haplotypes were not significantly distributed between the VL patients and healthy controls. Our study signifies no possible association of functional IL-4 polymorphisms with Indian VL and postulate other vital genes involved in the IL-4 pathway may provide genetic clues to elucidate of IL-4 regulation and immune-pathogenesis during VL.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Visceral Leishmaniasis; Leishmania Donovani; Interleukin 4; VNTR; India
ID Code:107752
Deposited On:01 Feb 2018 11:46
Last Modified:01 Feb 2018 11:46

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