A novel gene THSD7A is associated with obesity

Nizamuddin, S. ; Govindaraj, P. ; Saxena, S. ; Kashyap, M. ; Mishra, A. ; Singh, S. ; Rotti, H. ; Raval, R. ; Nayak, J. ; Bhat, B. K. ; Prasanna, B. V. ; Dhumal, V. R. ; Bhale, S. ; Joshi, K. S. ; Dedge, A. P. ; Bharadwaj, R. ; Gangadharan, G. G. ; Nair, S. ; Gopinath, P. M. ; Patwardhan, B. ; Kondaiah, P. ; Satyamoorthy, K. ; Valiathan, M. S. ; Thangaraj, K. (2015) A novel gene THSD7A is associated with obesity International Journal of Obesity, 39 (11). pp. 1662-1665. ISSN 0307-0565

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Official URL: http://www.nature.com/ijo/journal/v39/n11/pubmed/i...

Related URL: http://dx.doi.org/10.1038/ijo.2015.144


Body Mass Index (BMI) is a non-invasive measurement of obesity. It is commonly used for assessing adiposity and obesity-related risk prediction. Genetic differences between ethnic groups are important factors, which contribute to the variation in phenotypic effects. India inhabited by the first out-of-Africa human population and the contemporary Indian populations are admixture of two ancestral populations; Ancestral North Indians (ANI) and Ancestral South Indians (ASI). Although ANI are related to Europeans, ASI are not related to any group outside Indian-subcontinent. Hence, we expect novel genetic loci associated with BMI. In association analysis, we found eight genic SNPs in extreme of distribution (P ≤ 3.75 × 10−5), of which WWOX has already been reported to be associated with obesity-related traits hence excluded from further study. Interestingly, we observed rs1526538, an intronic SNP of THSD7A; a novel gene significantly associated with obesity (P = 2.88 × 10−5, 8.922 × 10−6 and 2.504 × 10−9 in discovery, replication and combined stages, respectively). THSD7A is neural N-glycoprotein, which promotes angiogenesis and it is well known that angiogenesis modulates obesity, adipose metabolism and insulin sensitivity, hence our result find a correlation. This information can be used for drug target, early diagnosis of obesity and treatment.

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