Vysabhattar, Raman ; Ganesh, K. N. (2008) Cyanuryl peptide nucleic acid: synthesis and DNA complexation properties Tetrahedron Letters, 49 (8). pp. 1314-1318. ISSN 0040-4039
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...
Related URL: http://dx.doi.org/10.1016/j.tetlet.2007.12.095
Abstract
The synthesis of cyanuryl PNA monomer (CyaPNA) 6 was achieved by direct N-monoalkylation of cyanuric acid with N-(2-Boc-aminoethyl)-N'-(bromoacetyl)glycyl ethyl ester 4. Compound 6 was incorporated as a T-mimic into PNA oligomers and biophysical studies on their triplexes/duplex complexes with complementary DNA oligomers indicated unusual stabilization of PNA:DNA hybrids when the cyanuryl unit was located in the middle of the PNA oligomer.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | PNA; Cyanuryl PNA |
| ID Code: | 10771 |
| Deposited On: | 09 Nov 2010 04:57 |
| Last Modified: | 31 May 2011 08:44 |
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