Crystal engineering: a holistic view

Desiraju, Gautam R. (2007) Crystal engineering: a holistic view Angewandte Chemie International Edition, 46 (44). pp. 8342-8356. ISSN 1433-7851

Full text not available from this repository.

Official URL:

Related URL:


Crystal engineering, the design of molecular solids, is the synthesis of functional solid-state structures from neutral or ionic building blocks, using intermolecular interactions in the design strategy. Hydrogen bonds, coordination bonds, and other less directed interactions define substructural patterns, referred to in the literature as supramolecular synthons and secondary building units. Crystal engineering has considerable overlap with supramolecular chemistry, X-ray crystallography, materials science, and solid-state chemistry and yet it is a distinct discipline in itself. The subject goes beyond the traditional divisions of organic, inorganic, and physical chemistry, and this makes for a very eclectic blend of ideas and techniques. The purpose of this Review is to highlight some current challenges in this rapidly evolving subject. Among the topics discussed are the nature of intermolecular interactions and their role in crystal design, the sometimes diverging perceptions of the geometrical and chemical models for a molecular crystal, the relationship of these models to polymorphism, knowledge-based computational prediction of crystal structures, and efforts at mapping the pathway of the crystallization reaction.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
Keywords:Crystal Engineering; Hydrogen Bonds; Intermolecular Interactions; Polymorphism; Supramolecular Chemistry
ID Code:10742
Deposited On:09 Nov 2010 05:01
Last Modified:30 May 2011 04:18

Repository Staff Only: item control page