Balamurugan, K. ; Subramanian, V. (2011) Interaction of polyalanine α-helix with carbon nanotube Journal of Biomedical Nanotechnology, 7 (1). pp. 89-90. ISSN 1550-7033
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Official URL: http://www.ingentaconnect.com/contentone/asp/jbn/2...
Related URL: http://dx.doi.org/10.1166/jbn.2011.1216
Abstract
The application of carbon nanotubes (CNT) in the area of biology such as Drug delivery vehicle and Biosensors calls for the basic understanding of the CNT's with biological macromolecules like proteins, DNA, Carbohydrates and lipids. CNT is known to be highly hydrophobic in nature. Our study reveals that the inherent hydrophobic nature of CNT is capable of disturbing the α-helical protein secondary structure. Thus our study provides mechanistic understanding of the loss in the α-helicity of the proteins in the presence of CNT. Our study reveals that the nanomaterials should be suitably modified for biological applications.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Scientific Publishers. |
| Keywords: | Alpha-Helix; CNT; Hydrogen Bonds; Hydrophobic Interaction |
| ID Code: | 107291 |
| Deposited On: | 01 Dec 2017 12:30 |
| Last Modified: | 01 Dec 2017 12:30 |
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