Chourasia, Mukesh ; Sastry, G. Madhavi ; Sastry, G. Narahari (2005) Proton binding sites and conformational analysis of H+K+-ATPase Biochemical and Biophysical Research Communications, 336 (3). pp. 961-966. ISSN 0006-291X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.bbrc.2005.08.205
Abstract
It is proposed that the hydronium ion, H3O+, binds to the E1 conformation of the α-subunit of gastric proton pump. The H3O+ binding cavities are characterized parametrically based on valence, sequence, geometry, and size considerations from comparative modeling. The cavities have scope for accommodating monovalent cations of different ionic radii. The H3O+ transport is proposed to be aided by arenes which are arranged regularly along the pump starting from N-domain through the transmembrane region. Step-by-step structural changes accompanying H3O+ occlusion are studied in detail. The observations corroborate well with earlier experimental studies.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | H+K+-ATPase; Cation Binding Cavity; Hydronium Ion; Aromatic Residues; Structural Deviations |
| ID Code: | 107101 |
| Deposited On: | 28 Jul 2017 06:19 |
| Last Modified: | 28 Jul 2017 06:19 |
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