Proton binding sites and conformational analysis of H+K+-ATPase

Chourasia, Mukesh ; Sastry, G. Madhavi ; Sastry, G. Narahari (2005) Proton binding sites and conformational analysis of H+K+-ATPase Biochemical and Biophysical Research Communications, 336 (3). pp. 961-966. ISSN 0006-291X

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It is proposed that the hydronium ion, H3O+, binds to the E1 conformation of the α-subunit of gastric proton pump. The H3O+ binding cavities are characterized parametrically based on valence, sequence, geometry, and size considerations from comparative modeling. The cavities have scope for accommodating monovalent cations of different ionic radii. The H3O+ transport is proposed to be aided by arenes which are arranged regularly along the pump starting from N-domain through the transmembrane region. Step-by-step structural changes accompanying H3O+ occlusion are studied in detail. The observations corroborate well with earlier experimental studies.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:H+K+-ATPase; Cation Binding Cavity; Hydronium Ion; Aromatic Residues; Structural Deviations
ID Code:107101
Deposited On:28 Jul 2017 06:19
Last Modified:28 Jul 2017 06:19

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