“On Water” C(sp³)–H functionalization/C–O/C–N bonds formations: synthesis of functionalized oxazolidines and imidazolidines

Abstract

On water oxidative C(sp³)–H functionalization/C–O/C–N bonds formations using tetrabutylammonium iodide as the catalyst and tert-butyl hydroperoxide in water (T-Hydro) as the oxidant affords a potential route for the construction of functionalized oxazolidines and imidazolidines. The reaction is simple, regioselective, and effective at moderate temperature with broad substrate scope. In the case of optically active substrates, the oxidative cyclization can be accomplished with high optical purities.