Expedient synthesis of tetrasubstituted pyrroles via a copper-catalyzed cascade inter-/intramolecular cyclization of 1,3-enynes carry a nitro group with amines

Bharathiraja, Ganesan ; Sengoden, Mani ; Kannan, Masanam ; Punniyamurthy, Tharmalingam (2015) Expedient synthesis of tetrasubstituted pyrroles via a copper-catalyzed cascade inter-/intramolecular cyclization of 1,3-enynes carry a nitro group with amines Organic and Biomolecular Chemistry, 13 (9). pp. 2786-2792. ISSN 1477-0520

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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2015...

Related URL: http://dx.doi.org/10.1039/C4OB02508C

Abstract

Various tetrasubstituted pyrroles/pyrazoles have been prepared from nitro-substituted 1,3-enynes with aromatic amines/hydrazines via a copper-catalyzed cascade aza-Michael addition, cyclization and aromatization at room temperature. This protocol is also effective for the synthesis of tetrasubstituted pyrazoles in high yields.

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ID Code:106835
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