A novel and simple asymmetric synthesis of CMI-977 (LDP-977): A potent anti-asthmatic drug lead

Gurjar, Mukund K. ; Murugaiah, A. M. S ; Radhakrishna, P. ; Ramana, C. V. ; Chorghade, Mukund S. (2003) A novel and simple asymmetric synthesis of CMI-977 (LDP-977): A potent anti-asthmatic drug lead Tetrahedron: Asymmetry, 14 (10). pp. 1363-1370. ISSN 0957-4166

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/S0957-4166(03)00157-5

Abstract

A practical gram scale asymmetric synthesis of CMI-977 is described. A tandem double elimination of an α-chlorooxirane and concomitant intramolecular nucleophilic substitution was used as the key step. Jacobsen hydrolytic kinetic resolution and Sharpless asymmetric epoxidation protocols were applied for the execution of the synthesis of the key chiral building block.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:106173
Deposited On:01 Feb 2018 16:47
Last Modified:01 Feb 2018 16:47

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