Toward a synthesis of the antitumor macrolide peloruside A: A chiral pool approach for the C(1)–C(11) segment

Gurjar, Mukund K. ; Pedduri, Yakambram ; Ramana, C .V. ; Puranik, Vedavati G. ; Gonnade, Rajesh G. (2004) Toward a synthesis of the antitumor macrolide peloruside A: A chiral pool approach for the C(1)–C(11) segment Tetrahedron letters, 45 (2). pp. 387-390. ISSN 0040-4039

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.tetlet.2003.10.153

Abstract

Dihydroxylation of the glucose derived α,β-unsaturated lactones 6 and 13 was found to be on the α-face of the pyranolactone ring exclusively. The resulting dihydroxylated compound from 13 has been used in a synthesis of the lactone 4, which corresponds to C(1)–C(11) of peloruside A.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Barbies Reaction; Ring Closing Metathesis; Dihydroxylation; Barton–McCombie Deoxygenation; Mitsunobu Reaction; Dess–Martin Periodinane
ID Code:106167
Deposited On:01 Feb 2018 16:57
Last Modified:01 Feb 2018 16:57

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