Asymmetric synthesis of α-methoxyarylacetic acid derivatives

Prasad, Kavirayani R. ; Chandrakumar, Appayee (2005) Asymmetric synthesis of α-methoxyarylacetic acid derivatives Tetrahedron: Asymmetry, 16 (11). pp. 1897-1900. ISSN 0957-4166

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.tetasy.2005.05.002

Abstract

Stereoselective synthesis of a series of 2-aryl-2-methoxyethanols was achieved from inexpensive chiral pool tartaric acid employing a diastereoselective reduction of a symmetrical 1,4-diaryldiketone as the key step. 2-Aryl-2-methoxyethanols were enantioselectively prepared in 80–90% yield.

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