More, Atul A. ; Ramana, Chepuri V. (2016) Total synthesis of integrastatin B enabled by a Benzofuran Oxidative Dearomatization Cascade Organic Letters, 18 (6). pp. 1458-1461. ISSN 1523-7060
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Official URL: http://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b...
Related URL: http://dx.doi.org/10.1021/acs.orglett.6b00404
Abstract
The first total synthesis of integrastatin B, a potent HIV-1 integrase inhibitor, has been accomplished in seven steps with a 17.9% overall yield employing easily accessible starting compounds. The Oxone-mediated oxidative benzofuran dearomatization cascade has been employed as the key skeletal construct to forge the central tetracyclic nucleus.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 105874 |
| Deposited On: | 01 Feb 2018 16:49 |
| Last Modified: | 01 Feb 2018 16:49 |
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