Enantiospecific formal total synthesis of iriomoteolide 3a

Kumar, S. Mothish ; Prasad, Kavirayani R. (2014) Enantiospecific formal total synthesis of iriomoteolide 3a Chemistry - An Asian Journal, 9 (12). pp. 3431-3439. ISSN 1861-4728

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/asia.20...

Related URL: http://dx.doi.org/10.1002/asia.201402593

Abstract

A formal total synthesis of the marine macrolide iriomoteolide 3a is described. Salient features of the synthesis include the elaboration of a β-keto phosphonate derived from D-(−)-tartaric acid and the extension of a chiral butyrolactone derived from L-glutamic acid. Ring-closing metathesis is employed to construct the macrolactone core of the natural product.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons, Inc.
Keywords:Iriomoteolide 3a; Lactones; Macrocycles; Natural Products; Total Synthesis
ID Code:105620
Deposited On:21 Dec 2017 12:01
Last Modified:21 Dec 2017 12:01

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