Total Synthesis of the Bis-silyl Ether of (+)-15-epi-Aetheramide A

Revu, Omkar ; Prasad, Kavirayani R. (2017) Total Synthesis of the Bis-silyl Ether of (+)-15-epi-Aetheramide A The Journal of Organic Chemistry, 82 (1). pp. 438-460. ISSN 0022-3263

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Synthesis of the macrolactone depsipeptide aetheramide A was attempted by three different approaches. The first approach to form the macrolactone involving macrolactonization to form the C1–C21 bond and the second approach using a ring-closing metathesis (RCM) strategy to form the C10–C11 olefinic bond failed. The third approach starting from R-mandelic acid, involving the RCM reaction to install the C18–C19 ring junction, was successful in assembling the macrolactone.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:105612
Deposited On:21 Dec 2017 12:02
Last Modified:21 Dec 2017 12:02

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