Synthesis, and characterization of ruthenium(II) polypyridyl complexes containing α-amino acids and its DNA binding behavior

Kumar, Prashant ; Singh, Ashish Kumar ; Saxena, Jitendra Kumar ; Pandey, Daya Shankar (2009) Synthesis, and characterization of ruthenium(II) polypyridyl complexes containing α-amino acids and its DNA binding behavior Journal of Organometallic Chemistry, 694 (22). pp. 3570-3579. ISSN 0022-328X

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.jorganchem.2009.07.014

Abstract

Reactivity of the ruthenium complexes [Ru(κ3-tptz)(PPh3)Cl2] (1) and [Ru(κ3-tpy)(PPh3)Cl2] (2) [tptz=2,4,6-tris(2-pyridyl)-1,3,5-triazine; tpy=2,2′:6′,2″-terpyridine] with several α-amino acids [glycine (gly); leucine (leu); isoleucine (isoleu); valine (val); tyrosine (tyr); proline (pro) and phenylalanine (phe)] have been investigated. Cationic complexes with the general formulations [Ru(κ3-L)(κ2-L″)(PPh3)]+ (L=tptz or tpy; L″=gly, leu, isoleu, val, tyr, pro, and phe] have been isolated as tetrafluoroborate salts. The resulting complexes have been thoroughly characterized by analytical, spectral and electrochemical studies. Molecular structures of the representative complexes [Ru(κ3-tptz)(val)(PPh3)]BF4 (6), [Ru(κ3-tpy)(leu)(PPh3)]BF4 (10) and [Ru(κ3-tpy)(tyr)(PPh3)]BF4 (13) have been determined crystallographically. The complexes [Ru(κ3-tptz)(leu)(PPh3)]BF4 (4), [Ru(κ3-tptz)(val)(PPh3)]BF4 (6), [Ru(κ3-tpy)(leu)(PPh3)]BF4 (10) [Ru(κ3-tpy)(tyr)(PPh3)] BF4•3H2O (13) exhibited DNA binding behavior and acted as mild Topo II inhibitors (10–40%). The complexes also inhibited heme polymerase activity of the malarial parasite Plasmodium yoelii lysate.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Ruthenium Complexes; Polypyridyl; Topoisomerase; Heme Polymerase
ID Code:105476
Deposited On:20 Apr 2017 10:59
Last Modified:20 Apr 2017 10:59

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