Does mesenchymal stem cell population in umbilical cord blood vary at different gestational periods?

Jain, Ashish ; Mathur, Nithin ; Jeevashankar, M. ; Mukhopadhyay, Ashok ; Agarwal, Ramesh ; Deorari, A. K. ; Paul, V. K. (2013) Does mesenchymal stem cell population in umbilical cord blood vary at different gestational periods? Indian Journal of Pediatrics, 80 (5). pp. 375-379. ISSN 0019-5456

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Official URL: http://link.springer.com/article/10.1007/s12098-01...

Related URL: http://dx.doi.org/10.1007/s12098-012-0844-3

Abstract

Objective: To identify and quantitatively determine Mesenchymal stem cells (MSCs) in the umbilical cord blood (UCB) of neonates born at different gestational periods. Methods: UCB was collected at birth in neonates of three different gestational groups. The mononuclear cells (MNCs) were phenotypically analyzed by flow cytometer. Results: The yield of total MNCs did not differ much with gestation; the average values were 22.6 ± 6.48 × 106 cells/ml. The MSCs were significantly higher in the lower gestation group. These were 0.0219 ± 0.012 %, 0.0044 ± 0.003 % and 0.0022 ± 0.003 % in 28 to 31 wk, 32 to 35 wk and >36 wk, respectively (P = 0.00). There was a significant inverse correlation between the gestational age and the presence of MSCs with a correlation co- efficient of −0.54 (P = 0.0001). Conclusions: The MSCs population was significantly higher in infants born at lesser gestation than those born at term gestation.

Item Type:Article
Source:Copyright of this article belongs to Springer Verlag.
Keywords:Gestational Age; Mesenchymal Stem Cells; Umbilical Cord Blood
ID Code:104315
Deposited On:08 Dec 2017 09:50
Last Modified:08 Dec 2017 09:50

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