Avula, Balakrishna ; Chiruvella, Kishore K. ; Reddy, Mudumala V. N. ; Reddy, Rajesh ; Nayak, Sandip K. ; Raghavan, Sathees C. ; Reddy, Cirandur S. (2010) Synthesis, characterization and evaluation of cytotoxicity of new aminophosphonic acid diesters in human leukemia cells Letters in Drug Design & Discovery, 7 (4). pp. 250-259. ISSN 1570-1808
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Official URL: http://www.ingentaconnect.com/content/ben/lddd/201...
Related URL: http://dx.doi.org/10.2174/157018010790945841
Abstract
A series of novel fluoroaminophosphates 4a-4j were synthesized by one-pot method in presence of Tetramethylguanidine (TMG) as a catalyst and were characterized by elemental analysis, FTIR, 1H, 13C, 31P, 19F NMR and mass spectra. All the title compounds were evaluated for in vitro cytotoxicity against leukemic cell line derived from Tcells of leukemia patient (CEM cells) by Trypan blue exclusion and MTT assays, and these were found to exert concentration dependent cytotoxic effects. Among them 4f, 4g & 4j possessed marked cytotoxicity. 4g (with IC50 value of 6 iM) had emerged as lead compound.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Bentham Science Publishers. |
| Keywords: | Aminophosphonate; CEM Cell; Cytotoxicity; Fluorine; Leukmia; Synthesis; TMG |
| ID Code: | 104310 |
| Deposited On: | 13 Apr 2017 12:04 |
| Last Modified: | 13 Apr 2017 12:04 |
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