Molecular mechanism of Endosulfan action in mammals

Sebastian, Robin ; Raghavan, Sathees C. (2017) Molecular mechanism of Endosulfan action in mammals Journal of Biosciences, 42 (1). pp. 149-153. ISSN 0250-5991

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Endosulfan is a broad-spectrum organochlorine pesticide, speculated to be detrimental to human health in areas of active exposure. However, the molecular insights to its mechanism of action remain poorly understood. In two recent studies, our group investigated the physiological and molecular aspects of endosulfan action using in vitro, ex vivo and in vivo analyses. The results showed that apart from reducing fertility levels in male animals, Endosulfan induced DNA damage that triggers compromised DNA damage response leading to undesirable processing of broken DNA ends. In this review, pesticide use especially of Endosulfan in the Indian scenario is summarized and the importance of our findings, especially the rationalized use of pesticides in the future, is emphasized.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:DNA Damage; Double-strand Break; Genomic; Instability; Infertility; MMEJ; NHEJ; Pesticides
ID Code:104284
Deposited On:01 Feb 2018 10:12
Last Modified:01 Feb 2018 10:12

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