Exposure to endosulfan can result in male infertility due to testicular atrophy and reduced sperm count

Sebastian, R. ; Raghavan, Sathees C. (2015) Exposure to endosulfan can result in male infertility due to testicular atrophy and reduced sperm count Cell Death Discovery, 1 . Article ID 15020, 10 pages. ISSN 2058-7716

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Official URL: http://www.nature.com/articles/cddiscovery201520

Related URL: http://dx.doi.org/10.1038/cddiscovery.2015.20

Abstract

Endosulfan (ES) is a widely used organochlorine pesticide and is speculated to be detrimental to human health. However, very little is known about mechanism of its genotoxicity. Using mouse model system, we show that exposure to ES affected physiology and cellular architecture of organs and tissues. Among all organs, damage to testes was extensive and it resulted in death of different testicular-cell populations. We find that the damage in testes resulted in qualitative and quantitative defects during spermatogenesis in a time-dependent manner, increasing epididymal reactive oxygen species levels, affecting sperm chromatin integrity. This further culminated in reduced number of epididymal sperms and actively motile sperms. Finally, we show that ES exposure affected fertility in male but not in female mice. Therefore, we demonstrate that ES exerts pathophysiological changes in mice, induces testicular atrophy, affects spermatogenesis, reduces quantity and vigour of epididymal sperm and leads to infertility in males.

Item Type:Article
Source:Copyright of this article belongs to Springer Nature.
ID Code:104179
Deposited On:04 Apr 2017 09:07
Last Modified:04 Apr 2017 09:09

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