Pluronic copolymer encapsulated SCR7 as a potential anticancer agent

John, Franklin ; George, Jinu ; Srivastava, Mrinal S ; Hassan, P. A. ; Aswal, V. K. ; Karki, Subhas S. ; Raghavan, Sathees C. (2015) Pluronic copolymer encapsulated SCR7 as a potential anticancer agent Faraday Discussions, 177 . pp. 155-161. ISSN 0301-7249

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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2015...

Related URL: http://dx.doi.org/10.1039/C4FD00176A

Abstract

Nonhomologous end joining (NHEJ) of DNA double strand breaks (DSBs) inside cells can be selectively inhibited by 5,6-bis-(benzylideneamino)-2-mercaptopyrimidin-4-ol (SCR7) which possesses anticancer properties. The hydrophobicity of SCR7 decreases its bioavailability which is a major setback in the utilization of this compound as a therapeutic agent. In order to circumvent the drawback of SCR7, we prepared a polymer encapsulated form of SCR7. The physical interaction of SCR7 and Pluronic® copolymer is evident from different analytical techniques. The in vitro cytotoxicity of the drug formulations is established using the MTT assay.

Item Type:Article
Source:Copyright of this article belongs to Royal Society of Chemistry.
ID Code:104169
Deposited On:04 Apr 2017 10:11
Last Modified:04 Apr 2017 10:11

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