Antiproliferative and tumor inhibitory studies of 2, 3 disubstituted 4-thiazolidinone derivatives

Sharath Kumar, Kothanahally S. ; Hanumappa, Ananda ; Vetrivel, Maruthai ; Hegde, Mahesh ; Girish, Yarabhally R. ; Byregowda, Thinnali R. ; Rao, Suguna ; Raghavan, Sathees C. ; Rangappa, Kanchugarakoppal S. (2015) Antiproliferative and tumor inhibitory studies of 2, 3 disubstituted 4-thiazolidinone derivatives Bioorganic & Medicinal Chemistry Letters, 25 (17). pp. 3616-3620. ISSN 0960-894X

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.bmcl.2015.06.069

Abstract

4-Thiazolidinone derivatives were synthesized using T3P®-DMSO media as a cyclodehydrating agent. All the molecules were tested for their cytotoxicity against leukemic cell lines. The compound 3-(4-bromophenyl)-2-(4-(dimethylamino)phenyl)thiazolidin-4-one (4e) with electron donating substituent at para position of phenyl ring displayed considerable cytotoxicity against Reh and Nalm6 cells with an IC50 value of 11.9 and 13.5 μM, respectively. Furthermore, the compound 4e tested for tumor regression studies induced by EAC in Swiss albino mouse. Both in vitro and in vivo results suggested significant antiproliferative activity of compound 4e in Reh cells and mouse tumor tissue treated with compound 4e showed multifocal areas of necrosis and numerous number of apoptotic cells.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:4-Thiazolidinone; T3P; Reh; EAC; Tumor Regression
ID Code:104144
Deposited On:07 Apr 2017 06:52
Last Modified:07 Apr 2017 06:52

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