Subramanian, Parthasarathi ; Indu, Satrajit ; Kaliappan, Krishna P. (2014) A one-pot copper catalyzed biomimetic route to N-heterocyclic amides from methyl ketones via oxidative C-C bond cleavage Organic Letters, 16 (23). pp. 6212-6215. ISSN 1523-7060
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Official URL: http://pubs.acs.org/doi/full/10.1021/ol5031266
Related URL: http://dx.doi.org/10.1021/ol5031266
Abstract
A direct one-pot Cu-catalyzed biomimetic oxidation of methyl ketones to pharmaceutically important N-heterocyclic amides is reported. The scope of the method is broad, scalable, and mild, and the reaction is tolerant with various acid, base sensitive functionalities with multiple heteroatoms and aryl halides. The extensive mechanistic studies suggest that this reaction follows the Luciferin-Luciferase-like pathway.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 103957 |
| Deposited On: | 12 Jun 2017 09:45 |
| Last Modified: | 12 Jun 2017 09:45 |
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