Synthesis of 1,8-dioxooctahydroxanthene C-nucleosides

Manna, Chinmoy ; Samanta, Sintu Kumar ; Ghosh, Sudip Kumar ; Pathak, Tanmaya (2013) Synthesis of 1,8-dioxooctahydroxanthene C-nucleosides Tetrahedron Letters, 54 (30). pp. 3971-3973. ISSN 0040-4039

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.tetlet.2013.05.067

Abstract

Since reactions between carbohydrates and cyclic 1,3-dicarbonyl compounds do not produce 1,8-dioxooctahydroxanthenes in general, reaction strategies have been devised to generate new 1,8-dioxooctahydroxanthene C-nucleosides by reacting sugars masked with acid-labile protecting groups and with free hydroxyl groups with 1,3-cyclohexanedione or dimedone. Some of these compounds are more cytotoxic to the cancer cells than against normal fibroblasts.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:1,8-Dioxooctahydroxanthene C-nucleosides; Cyclic Sugar Aldehyde; 1,3-Dicarbonyls; Knoevenagel Reaction; Cytotoxicity
ID Code:103839
Deposited On:21 Mar 2017 05:17
Last Modified:21 Mar 2017 05:17

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