Inhibition of miR-21 by 3′/5′-serinyl-capped 2′-O-methyl RNA interspersed with 2′-O-(2-amino-3-methoxypropyl) uridine units

Nahar, Smita ; Kotikam, Venubabu ; Kumar, Vaijayanti A. ; Maiti, Souvik (2016) Inhibition of miR-21 by 3′/5′-serinyl-capped 2′-O-methyl RNA interspersed with 2′-O-(2-amino-3-methoxypropyl) uridine units Nucleic Acid Therapeutics, 26 (5). pp. 327-334. ISSN 2159-3337

Full text not available from this repository.

Official URL: http://online.liebertpub.com/doi/10.1089/nat.2015....

Related URL: http://dx.doi.org/10.1089/nat.2015.0591

Abstract

miRNAs are highly conserved class of small ncRNAs whose involvement in human pathophysiologies is extensively investigated. MiR-21 is a well established oncogenic miRNA whose deregulation plays a significant role in onset and progression of cancer. The need of novel approaches to downregulate miR-21 is rapidly expanding. Potent inhibition of miR-21 is achieved by chemically modified 2′-O-methyl RNA oligonucleotide. The serinol capping at 3′ and 5′ends and the interspersed 2′-O-(R-2-amino-3-methoxypropyl) uridine units enhance the nuclease resistance and efficacy of 2′-O-methyl RNA for the inhibition of miR-21. This represents a simple and novel modification for developing oligonucleotide-based therapeutics.

Item Type:Article
Source:Copyright of this article belongs to Mary Ann Leibert.
Keywords:microRNA; Cancer; Noncoding RNA; Oligonucleotides; Antagomirs
ID Code:103625
Deposited On:04 Apr 2017 05:36
Last Modified:04 Apr 2017 05:36

Repository Staff Only: item control page