Bose, Tanaya ; Banerjee, Anjan ; Nahar, Smita ; Maiti, Souvik ; Kumar, Vaijayanti A. (2015) β,γ-Bis-substituted PNA with configurational and conformational switch: preferred binding to cDNA/RNA and cell-uptake studies Chemical Communications, 51 (36). pp. 7693-7696. ISSN 1359-7345
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Official URL: http://pubs.rsc.org/en/content/articlelanding/2015...
Related URL: http://dx.doi.org/10.1039/C5CC00891C
Abstract
(S,S)- and (R,R)-β,γ-Bis-substituted PNAs were synthesized from the C-2 symmetric vicinal diamine system embedded in 1,4 dihydroxybutane and 1,4-dimethoxybutane scaffolds. (R,R)-β,γ-Bis-methoxymethyl-PNA derived from D-tartaric acid was found to be in the right configuration and conformation to be an excellent mimic of PNA, endowed with superior ability to enter into cells.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry. |
| ID Code: | 103621 |
| Deposited On: | 04 Apr 2017 05:53 |
| Last Modified: | 04 Apr 2017 05:53 |
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