The tale of RNA G-quadruplex

Agarwala, Prachi ; Pandey, Satyaprakash ; Maiti, Souvik (2015) The tale of RNA G-quadruplex Organic and Biomolecular Chemistry, 13 (20). pp. 5570-5585. ISSN 1477-0520

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G-quadruplexes are non-canonical secondary structures found in guanine rich regions of DNA and RNA. Reports have indicated the wide occurrence of RNA G-quadruplexes across the transcriptome in various regions of mRNAs and non-coding RNAs. RNA G-quadruplexes have been implicated in playing an important role in translational regulation, mRNA processing events and maintenance of chromosomal end integrity. In this review, we summarize the structural and functional aspects of RNA G-quadruplexes with emphasis on recent progress to understand the protein/trans factors binding these motifs. With the revelation of the importance of these secondary structures as regulatory modules in biology, we have also evaluated the various advancements towards targeting these structures and the challenges associated with them. Apart from this, numerous potential applications of this secondary motif have also been discussed.

Item Type:Article
Source:Copyright of this article belongs to Royal Society of Chemistry.
ID Code:103619
Deposited On:04 Apr 2017 05:54
Last Modified:04 Apr 2017 05:54

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