Nanoparticles from cationic copolymer and DNA that are soluble and stable in common organic solvents

Ganguli, Munia ; Jayachandran, Kizhakkedathu N. ; Maiti, Souvik (2004) Nanoparticles from cationic copolymer and DNA that are soluble and stable in common organic solvents Journal of the American Chemical Society, 126 (1). pp. 26-27. ISSN 0002-7863

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Official URL: http://pubs.acs.org/doi/abs/10.1021/ja037534v

Related URL: http://dx.doi.org/10.1021/ja037534v

Abstract

DNA by virtue of its superlative ability to self-assemble has found use beyond biological research in the design and fabrication of nanomaterials. However, developing novel DNA-based materials for chemical applications might be restricted due to the insoluble nature of DNA in most common organic solvents. In this Communication, we are reporting the first demonstration of making DNA soluble in a variety of nonbiological solvents such as acetonitrile, benzene, dimethyl sulfoxide (DMSO), and tetrahydrofuran with the help of poly(ethylene glycol) (PEG)-based cationic random copolymers. Because of complex formation between cationic copolymer and anionic DNA, nanoparticles are formed. These nanoparticles are expected to exhibit micelle-like structures with a nanometric core of cationic units neutralized by phosphate anions of DNA, surrounded by a shell of PEG segments. As PEG is soluble in the organic solvents used in this study, nanoparticles are stable in these solvents, making entrapped DNA soluble in these organic solvents.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:103385
Deposited On:02 Feb 2018 03:47
Last Modified:02 Feb 2018 03:47

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