Salunke, Deepak B. ; Ravi, Dyavar S. ; Pore, Vandana S. ; Mitra, Debashis ; Hazra, Braja G. (2006) Amino functionalized novel cholic acid derivatives induce HIV-1 replication and syncytia formation in T cells Journal of Medicinal Chemistry, 49 (8). pp. 2652-2655. ISSN 0022-2623
Full text not available from this repository.
Official URL: http://pubs.acs.org/doi/abs/10.1021/jm051114u
Related URL: http://dx.doi.org/10.1021/jm051114u
Abstract
Synthesis of C-11 azido/amino functionalized cholic acid derivatives has been achieved in excellent yields. Contrary to the previous prediction of analogous compounds to be HIV-1 protease inhibitors, in the present study these novel cholic acid derivatives induced host cell fusion during the progress of HIV-1 infection and produced multinucleated giant cells. This is the first report of syncytia induction and enhancement of viral replication in HIV-1 infected T cells by cholic acid derivatives.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 103219 |
| Deposited On: | 05 Feb 2017 16:46 |
| Last Modified: | 05 Feb 2017 16:46 |
Repository Staff Only: item control page
