Kundu, M. ; Basu, J. ; Chakrabarti, P. ; Rakshit, M. M. (1989) Abnormalities in the erythrocyte membrane in acute lymphoid leukaemia Biochemical Journal, 258 (3). pp. 903-906. ISSN 0264-6021
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Official URL: http://www.biochemj.org/content/258/3/903
Related URL: http://dx.doi.org/10.1042/bj2580903
Abstract
Erythrocytes from patients suffering from acute lymphoid leukaemia (ALL) show decreased proportions of spectrin tetrameters and altered spatial distribution of band 4.1 and ankyrins. These abnormalities of the cytoskeleton are probably responsible for altered membrane fluidity and transbilayer distribution of phosphatidylethanolamine in ALL. ALL is associated with severe anaemia and usually, but not always, with overproduction of lymphocytes. To our knowledge, this is the first report of abnormalities in the erythrocyte membrane in ALL which may, in part, be responsible for the observed anaemia.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Portland Press. |
| ID Code: | 102928 |
| Deposited On: | 11 Mar 2017 13:34 |
| Last Modified: | 11 Mar 2017 13:34 |
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