DSCAM, a highly conserved gene in mammals, expressed in differentiating mouse brain

Agarwala, Kishan Lal ; Ganesh, Subramaniam ; Amano, Kenji ; Suzuki, Toshimitsu ; Yamakawa, Kazuhiro (2001) DSCAM, a highly conserved gene in mammals, expressed in differentiating mouse brain Biochemical and Biophysical Research Communications, 281 (3). pp. 697-705. ISSN 0006-291X

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1006/bbrc.2001.4420


Down Syndrome Cell Adhesion molecule (DSCAM) is a member of the immunoglobulin superfamily, and represents a novel class of neuronal cell adhesion molecules. In order to understand the cellular functions of DSCAM, we isolated full-length mouse and human cDNA clones, and analysed its expression during mouse development and differentiation. Sequence analysis of the human DSCAM cDNA predicted at least 33 exons that are distributed over 840 kb. When compared to human DSCAM, the mouse homologue showed 90 and 98% identity at the nucleotide and amino acid levels, respectively. In mouse, DSCAM is located on 16C, the syntenic region for human chromosome band 21q22 and also the region duplicated in mouse DS models. DSCAM gene is predicted to encode an ∼220-kDa protein, and its expression shows dynamic changes that correlate with neuronal differentiation during mouse development. Our results suggest that DSCAM may play critical roles in the formation and maintenance of specific neuronal networks in brain.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:DSCAM; Mouse; Immunoglobulin Superfamily; Cell Adhesion Molecule; Development; Expression; Down Syndrome
ID Code:102830
Deposited On:01 Feb 2017 16:53
Last Modified:01 Feb 2017 16:53

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