Association between inflammatory gene polymorphisms and coronary artery disease in an Indian population

Banerjee, Indranil ; Pandey, Umeshwar ; Hasan, Omer M. ; Parihar, Rashmi ; Tripathi, Vijaya ; Ganesh, Subramaniam (2009) Association between inflammatory gene polymorphisms and coronary artery disease in an Indian population Journal of Thrombosis and Thrombolysis, 27 (1). pp. 88-94. ISSN 0929-5305

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Background: Inflammation is one of the major components of atherosclerosis which is the underlying disorder that leads to various diseases including coronary artery disease (CAD). Genes that are involved in the inflammatory processes are therefore good candidates for the risk of CAD. Variations in the genes involved in various molecular pathways of inflammation have been implicated to exaggerated atherosclerosis and the risk of cardiovascular diseases. In this study, we performed a genetic association study on the single nucleotide polymorphisms (SNPs) present in the genes CD14 (−159 C/T), TNFα (−308 G/A), IL-1α (−889 C/T), IL-6 (−174 G/C), PSMA6 (−8 C/G), and PDE4D (SNP83 T/C, respectively) in order to discern their possible role in the susceptibility to CAD in a North Indian population. Methods: Angiographically proven CAD patients (n = 210) and age, sex and ethnically matched normal healthy controls (n = 232) were recruited for this case-control study. Genotypes were determined by PCR–RFLP method. Chi-square and logistic regression analyses were performed to compare the genotype and allele frequencies between the patient and the control groups. Results: None of the SNPs showed significant association with CAD in the study population before and after adjustment for the confounding risk factors like age, sex, hypertension, smoking habit, and diabetes. Conclusion This study was unable to demonstrate any association between the six gene variants tested and CAD in the North Indian population.

Item Type:Article
Source:Copyright of this article belongs to Springer Verlag.
Keywords:Coronary Artery Disease; Inflammation; Gene Polymorphism; Association
ID Code:102766
Deposited On:02 Feb 2017 04:49
Last Modified:02 Feb 2017 04:49

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