Satellite III non-coding RNAs show distinct and stress-specific patterns of induction

Sengupta, Sonali ; Parihar, Rashmi ; Ganesh, Subramaniam (2009) Satellite III non-coding RNAs show distinct and stress-specific patterns of induction Biochemical and Biophysical Research Communications, 382 (1). pp. 102-107. ISSN 0006-291X

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.bbrc.2009.02.137

Abstract

The heat shock response in human cells is associated with the transcription of satellite III repeats (SatIII) located in the 9q12 locus. Upon induction, the SatIII transcripts remain associated with the locus and recruit several transcription and splicing factors to form the nuclear stress bodies (nSBs). The nSBs are thought to modulate epigenetic changes during the heat shock response. We demonstrate here that the nSBs are induced by a variety of stressors and show stress-specific patterns of induction. While the transcription factor HSF1 is required for the induction of SatIII locus by the stressors tested, its specific role in the transcriptional process appears to be stress dependent. Our results suggest the existence of multiple transcriptional loci for the SatIII transcripts and that their activation might depend upon the type of stressors. Thus, induction of SatIII transcripts appears to be a generic response to a variety of stress conditions.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Stress Response; Heat Shock Factor 1; Epigenetic Modification; RNA Splicing
ID Code:102762
Deposited On:02 Feb 2017 04:51
Last Modified:02 Feb 2017 04:51

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