Reviewing Chandipura: a vesiculovirus in human epidemics

Basak, Soumen ; Mondal, Arindam ; Polley, Smarajit ; Mukhopadhyay, Subhradip ; Chattopadhyay, Dhrubajyoti (2007) Reviewing Chandipura: a vesiculovirus in human epidemics Bioscience Reports, 27 (4-5). pp. 275-298. ISSN 0144-8463

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Chandipura virus, a member of the rhabdoviridae family and vesiculovirus genera, has recently emerged as human pathogen that is associated with a number of outbreaks in different parts of India. Although, the virus closely resembles with the prototype vesiculovirus, Vesicular Stomatitis Virus, it could be readily distinguished by its ability to infect humans. Studies on Chandipura virus while shed light into distinct stages of viral infection; it may also allow us to identify potential drug targets for antiviral therapy. In this review, we have summarized our current understanding of Chandipura virus life cycle at the molecular detail with particular interest in viral RNA metabolisms, namely transcription, replication and packaging of viral RNA into nucleocapsid structure. Contemporary research on otherwise extensively studied family member Vesicular Stomatitis Virus has also been addressed to present a more comprehensive picture of vesiculovirus life cycle. Finally, we reveal examples of protein economy in Chandipura virus life-cycle whereby each viral protein has evolved complexity to perform multiple tasks.

Item Type:Article
Source:Copyright of this article belongs to Portland Press Limited.
Keywords:Chandipura Virus; Transcription; Replication; Encapsidation; Leader RNA; Nucleocapsid Protein; Phosphoprotein; Economy; Multi-functional
ID Code:10269
Deposited On:04 Nov 2010 06:45
Last Modified:16 May 2016 19:55

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