Effect of shear force on the separation of double-stranded DNA

Abstract

Using the Langevin dynamics simulation, we have studied the effects of shear force on the rupture of short double-stranded DNA at different temperatures. We show that the rupture force increases linearly with chain length and approaches the asymptotic value in accordance with the experiment. The qualitative nature of these curves remains almost the same for different temperatures but with a shift in the force. We observe three different regimes in the extension of covalent bonds (backbone) under shear force.