Probability distribution analysis of force induced unzipping of DNA

Kumar, Sanjay ; Giri, Debaprasad (2006) Probability distribution analysis of force induced unzipping of DNA The Journal of Chemical Physics, 125 (4). Article ID 044905. ISSN 0021-9606

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Official URL: http://aip.scitation.org/doi/full/10.1063/1.221911...

Related URL: http://dx.doi.org/10.1063/1.2219115

Abstract

We present a semimicroscopic model of dsDNA by incorporating the directional nature of hydrogen bond to describe the force induced unzipping transition. Using exact enumeration technique, we obtain the force-temperature and the force-extension curves and compare our results with the other models of dsDNA. The model proposed by us is rich enough to describe the basic mechanism of dsDNA unzipping and predicts the existence of an “eye phase.” We show oscillations in the probability distribution function during unzipping. Effects of stacking energies on the melting profile have also been studied.

Item Type:Article
Source:Copyright of this article belongs to American Institute of Physics.
Keywords:Polymers; DNA; Phase Diagrams; Entropy; Probability Theory
ID Code:102639
Deposited On:02 Feb 2018 04:13
Last Modified:02 Feb 2018 04:13

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