Kant, Rama ; Singh, Vishal ; Nath, Gopal ; Awasthi, Satish Kumar ; Agarwal, Alka (2016) Design, synthesis and biological evaluation of ciprofloxacin tethered bis-1,2,3-triazole conjugates as potent antibacterial agents European Journal of Medicinal Chemistry, 124 . pp. 218-228. ISSN 0223-5234
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.ejmech.2016.08.031
Abstract
A series of new bis-1,2,3-triazole linked ciprofloxacin conjugates was designed, synthesized and evaluated in vitro antibacterial activity against a panel of clinically relevant bacteria. A significant part of the compounds displayed enhanced activity against both Gram-positive and Gram-negative species of bacteria as compared to the parent drug. Additionally, negligible toxicity profile of compounds indicates that they may act a good antibiotic in future. Despite relatively small number of synthesized conjugates, it was possible to observe important dependences between their structure and activity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | 1,2,3-Triazole Conjugates; Ciprofloxacin; Antibacterial Activity; Hemotoxicity |
| ID Code: | 102438 |
| Deposited On: | 15 Jun 2017 10:37 |
| Last Modified: | 15 Jun 2017 10:37 |
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