Kaur, Navjot ; Singh, Jatinder ; Kamboj, Sukhdev S. ; Agrewala, Javed N. ; Kaur, Manpreet (2005) Two novel lectins from Parkia biglandulosa and Parkia roxburghii: isolation, physicochemical characterization, mitogenicity and anti-proliferative activity Protein and Peptide Letters, 12 (6). pp. 589-595. ISSN 0929-8665
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Official URL: http://www.ingentaconnect.com/contentone/ben/ppl/2...
Related URL: http://dx.doi.org/10.2174/0929866054395725
Abstract
Two mannose/glucose specific seed lectins were isolated from Parkia biglandulosa and Parkia roxburghii and were characterized w.r.t various physicochemical properties. Unlike other Parkia lectins a comparison of native and subunit molecular mass showed that both Parkia lectins were heterotetramers. Parkia biglandulosa lectin was found to be T-cell mitogen as revealed by IL-2 bioassay. These lectins showed anti-proliferative effect on two murine macrophage cancer cell lines i.e. P 388DI (50%) and J774 (70%). In addition Parkia roxburghii also inhibited proliferation of HB98 (65.47%), a B-cell hybridoma cell line.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Bentham Science Publishers Ltd. |
| Keywords: | Anti-proliferative; Cell Lines; Lectin; Leguminosae; Mannose; Mitogenic; Parkia |
| ID Code: | 101941 |
| Deposited On: | 12 Jan 2017 11:59 |
| Last Modified: | 12 Jan 2017 11:59 |
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