Crystallographic studies of the extracytoplasmic function σ factor σJ from Mycobacterium tuberculosis

Goutam, Kapil ; Gupta, Arvind Kumar ; Gopal, Balasubramanian (2015) Crystallographic studies of the extracytoplasmic function σ factor σJ from Mycobacterium tuberculosis Acta Crystallographica Section F, 71 (8). pp. 946-950. ISSN 1744-3091

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Official URL: http://scripts.iucr.org/cgi-bin/paper?S2053230X150...

Related URL: http://dx.doi.org/10.1107/S2053230X15009577

Abstract

Mycobacterium tuberculosis has multiple σ factors which enable the bacterium to reprogram its transcriptional machinery under diverse environmental conditions. σJ, an extracytoplasmic function σ factor, is upregulated in late stationary phase cultures and during human macrophage infection. σJ governs the cellular response to hydrogen peroxide-mediated oxidative stress. σJ differs from other canonical σ factors owing to the presence of a SnoaL_2 domain at the C-terminus. σJ crystals belonged to the tetragonal space group I422, with unit-cell parameters a = b = 133.85, c = 75.08 Å. Diffraction data were collected to 2.16 Å resolution on the BM14 beamline at the European Synchrotron Radiation Facility (ESRF).

Item Type:Article
Source:Copyright of this article belongs to International Union of Crystallography.
Keywords:σ Factor; Sigma Factor; Snoal_2 Domain; Potential Drug Target
ID Code:101919
Deposited On:09 Mar 2018 11:23
Last Modified:09 Mar 2018 11:23

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