Gowthaman, Uthaman ; Chodisetti, Sathi Babu ; Agrewala, Javed N. (2010) T cell help to B cells in germinal centers: putting the jigsaw together International Reviews of Immunology, 29 (4). pp. 403-420. ISSN 0883-0185
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Official URL: http://www.tandfonline.com/doi/abs/10.3109/0883018...
Related URL: http://dx.doi.org/10.3109/08830185.2010.496503
Abstract
The Germinal Center (GC) reaction supports the processes of affinity maturation and class switching in B cells that result in long-lasting humoral immunity. CD4+ T follicular helper cells (Tfh) participate in the GC reaction to help B cells. However, recent studies highlight the heterogeneity of CD4+ T cells in GCs, which confounds the understanding of Tfh cells. Based on many recent studies, we have tried to form a working model on the niche of Tfh cells in GCs. We have also addressed whether Tfh cells are a distinct lineage and how they may be generated to help B cells.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Informa Healthcare. |
| Keywords: | Follicular T Helper Cells, B Cells; Germinal Centers; T Cell Subsets |
| ID Code: | 101909 |
| Deposited On: | 11 Jan 2017 12:02 |
| Last Modified: | 11 Jan 2017 12:02 |
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