Siddiqui, Kaneez Fatima ; Amir, Mohammed ; Agrewala, Javed Naim (2011) Understanding the biology of 16 kDa antigen of Mycobacterium tuberculosis: scope in diagnosis, vaccine design and therapy Critical Reviews in Microbiology, 37 (4). pp. 349-357. ISSN 1040-841X
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Official URL: http://www.tandfonline.com/doi/abs/10.3109/1040841...
Related URL: http://dx.doi.org/10.3109/1040841X.2011.606425
Abstract
Heat Shock Proteins (HSPs) are conserved and ubiquitous house keeping entities that act as molecular chaperones, which protect the cell from damage during stress. One such HSP, the 16 kDa antigen, from Mycobacterium tuberculosis (Mtb) has received considerable attention due to its importance in tuberculosis latency and immunodominant property. In this article, we discuss about the potential role of 16 kDa antigen of Mtb in latency, its expression, regulation and implication in host immune response. We also highlight the scope of employing 16 kDa in early diagnosis, development of vaccine and as a potential drug target.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Taylor & Francis. |
| Keywords: | Mycobacterium tuberculosis; 16 kDa Antigen; Latency; Vaccine; Diagnosis |
| ID Code: | 101905 |
| Deposited On: | 10 Jan 2017 12:33 |
| Last Modified: | 10 Jan 2017 12:33 |
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