Kaur, Jaspreet ; Singh, Nasib ; Singh, Biswajit Kumar ; Dube, Anuradha ; Tripathi, Rama Pati ; Singh, Prashant ; Singh, Neeloo (2010) Leishmania donovani: oral therapy with glycosyl 1,4-dihydropyridine analogue showing apoptosis like phenotypes targeting pteridine reductase 1 in intracellular amastigotes Experimental Parasitology, 125 (3). pp. 310-314. ISSN 0014-4894
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.exppara.2010.02.011
Abstract
Glycosyl 1,4-dihydropyridine analogue (2,6-dimethyl-4-(3-O-benzyl-1,2-O-isopropylidene-β-l-threo pentofuranos-4-yl)-1-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester) synthesized in our laboratory, inhibited Leishmania donovani infection in vitro and in hamsters (Mesocricetus auratus) when administered orally. This analogue is nontoxic, cell-permeable and orally effective. This glycosyl dihydropyridine analogue functioned through arrest of cells in sub-G0/G1-phase, triggering mitochondrial membrane depolarization-mediated programmed cell death of the intracellular amastigotes.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Leishmania donovani; Dihydropyridine; Antileishmanial Activity; Flow Cytometry; Cell Cycle Arrest |
| ID Code: | 101832 |
| Deposited On: | 11 Mar 2017 14:54 |
| Last Modified: | 11 Mar 2017 14:54 |
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