Maurya, Rakesh ; Gupta, Prasoon ; Chand, Kailash ; Kumar, Manmeet ; Dixit, Preety ; Singh, Nasib ; Dube, Anuradha (2009) Constituents of Tinospora sinensis and their antileishmanial activity against Leishmania donovani Natural Product Research, 23 (12). pp. 1134-1143. ISSN 1478-6419
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Official URL: http://www.tandfonline.com/doi/abs/10.1080/1478641...
Related URL: http://dx.doi.org/10.1080/14786410802682239
Abstract
Two new compounds 4-methyl-heptadec-6-enoic acid ethyl ester (2) and 3-hydroxy-2,9,11-trimethoxy-5,6-dihydro isoquino[3,2-a]isoquinolinylium (7) were isolated from an ethanolic extract of the stems of Tinospora sinensis, along with six known compounds (1, 3–6 and 8). The structures of new compounds were established on the basis of detailed spectroscopic studies. Compound 7 exhibited the highest in vitro antileishmanial activity against Leishmania donovani promastigotes and intracellular amastigotes, whereas compounds 2, 4, 5 and 6 demonstrated moderate activity. Other compounds were found to be inactive.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Taylor & Francis. |
| Keywords: | Tinospora sinensis; Menispermaceae; Alkaloids; Lignans; Leishmania donovani; Immunomodulation; Antileishmanial |
| ID Code: | 101827 |
| Deposited On: | 11 Mar 2017 14:57 |
| Last Modified: | 11 Mar 2017 14:57 |
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