Dube, Anuradha ; Sharma, P. ; Srivastava, J. K. ; Misra, A. ; Naik, S. ; Katiyar, J. C. (1998) Vaccination of langur monkeys (Presbytis entellus) against Leishmania donovani with autoclaved L. major plus BCG Parasitology, 116 (3). pp. 219-221. ISSN 0031-1820
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Official URL: https://www.cambridge.org/core/journals/parasitolo...
Related URL: http://dx.doi.org/10.1017/S0031182097002175
Abstract
The protective potential of killed Leishmania major (ALM) along with BCG was evaluated against L. donovani in Indian langur monkeys in single and triple dose schedules. A delayed protection was observed in monkeys after a single dose schedule of ALM (3 mg)+BCG (3 mg) given intradermally 2 months before intravenous challenge with L. donovani. Triple dose schedule each of 1 mg ALM+1 mg BCG was more effective. The status remained unchanged until the end of the experiment (approximately 8 months). The study indicates that a combination of ALM+BCG may be a good candidate vaccine for exploiting against human Kala-azar.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Cambridge University Press. |
| Keywords: | Leishmania Major; BCGL; L. donovani; Indian Langur Monkeys; Cross-Protection; Vaccination |
| ID Code: | 101791 |
| Deposited On: | 11 Mar 2017 15:22 |
| Last Modified: | 11 Mar 2017 15:22 |
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