Proline repeats, in cis- and trans-positions, confer protection against the toxicity of misfolded proteins in a mammalian cellular model

Siwach, Pratibha ; Sengupta, Sonali ; Parihar, Rashmi ; Ganesh, Subramaniam (2011) Proline repeats, in cis- and trans-positions, confer protection against the toxicity of misfolded proteins in a mammalian cellular model Neuroscience Research, 70 (4). pp. 435-441. ISSN 0168-0102

Full text not available from this repository.

Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.neures.2011.05.001

Abstract

A broad range of neurodegenerative disorders result from the cytotoxicity conferred by aberrantly folded mutant proteins. Intriguingly, the cytotoxicity and aggregation property of a few mutant proteins are known to be modulated by the flanking sequences. One of such modulators is the proline repeat tract. Using a mammalian cellular model, we show here that proline repeat tract, both in cis- and in trans-positions, ameliorate the cytotoxicity of wide range of misfolded proteins coded by synthetic constructs. We further show that the proline repeat tract could possibly confer protection against the cytotoxicity of misfolded proteins by altering their conformation at the time of their synthesis. Thus, our study elucidates the mechanism by which the proline repeat tract might ameliorate the toxicity of misfolded proteins, and opens up new therapeutic modalities for disorders caused by cytotoxic misfolded proteins.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Homopolymeric Repeats; Repeat Expansion Disorders; Protein Misfolding; Proline Repeats; Cytotoxicity; Cis/Trans-Acting Factors
ID Code:101755
Deposited On:03 Feb 2017 16:27
Last Modified:03 Feb 2017 16:27

Repository Staff Only: item control page